Application Note

Biosimilar Comparison and Accelerated Stability Predictions Based on <2% Secondary Structure Differences Using Microfluidic Modulation Spectroscopy (MMS)

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Application Note

This Application Note Includes:

  • Microfluidic Modulation Spectroscopy (MMS) as a tool that measures differences in secondary structure of <2% between samples due to highly reproducible replicate measurements generated by the AQS3pro.
  • The power of MMS to predict the relative order of sample stability based on very small secondary structure differences detected between sample pairs of biosimilar molecules incubated at 4°C and 30°C for 8 weeks.

Biosimilar Structure Analysis And Stability Predictions

Biosimilar molecules are designed to mimic innovator molecules that have been approved and are available on the market, providing others within the industry an opportunity to create structurally similar therapeutic medicines for greater patient accessibility. This application note explores the success of Microfluidic Modulation Spectroscopy (MMS) as an automated tool for detecting and differentiating small changes in secondary structure and predicting overall stability of biosimilars for their long-term stability studies. 

Change How You See Biomolecules

Microfluidic Modulation Spectroscopy provides a powerful alternative, producing consistently reproducible data that goes beyond that supplied by current techniques. The high-performance fully automated AQS3pro system and AQS3delta analytics package allow scientists to quickly and easily run samples, process data and gain insight.


Next generation in protein structure determination.

The AQS³pro powered by Microfluidic Modulation Spectroscopy is the next generation infrared based spectroscopy platform for protein structure determination. It represents a novel tool that will strengthen you bioanalytical tool kit and provide critical insights into protein based drug development.
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Access the latest on-demand RedShiftBio webinar.


Learn how industry leaders are using our MMS technology in their lab.


Read the latest peer-reviewed publications on our MMS technology.

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