This Application Note Includes:
Characterizing biologic drug products is crucial in drug development and the presence of organic solvents and optically active excipients typically hinders traditional characterization techniques. RedshiftBio has developed the AQS3pro, a novel characterization system powered by Microfluidic Modulation Spectroscopy (MMS) as a solution to overcoming these obstacles. MMS combines Infrared (IR) spectroscopy with automatic sample handling and a micro-flow cell for accurate measurements with no buffer interference. The system uses rapid modulation between a sample and its reference buffer to generate a differential spectrum for the most accurate buffer subtraction. This app note demonstrates that MMS can be used as an alternative to traditional secondary structure determination tools, when organic solvents and optically active excipients are present.
Next generation in protein structure determination.