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Application note

This Application Note Includes:

In this App, RedShitBio provides an overview of the AQS3pro while it was still in late stages of development
Simplifies measurement workflow
Extends concentration range
Measures secondary structure and fingerprinting with increased accuracy
Demonstrates significant increases in sensitivity, dynamic range, and utility for determination of protein similarity (fingerprinting), quantitation, protein secondary structure, and protein stability and aggregation through thermal and chemical denaturation methods with microfluidics to enhance sensitivity and accuracy
Achieves higher sensitivity across a wider concentration range when measuring both chemical and thermal stability, in addition to aggregation

Application Note Introduction

RedShiftBio’s MMS analyzer combines laser spectroscopy, microfluidics, and signal processing to provide a powerful, efficient tool that uses mid-infrared to directly probe the protein backbone and provide information on higher-order structure, aggregate formation, protein stability, and concentration. Unlike other techniques, proteins can be measured over a broad concentration range with relative ease in a variety of environments without the issues of background fluorescence and light scattering, and complications related to protein size.

Change How You See Biomolecules

Microfluidic Modulation Spectroscopy provides a powerful alternative, producing consistently reproducible data that goes beyond that supplied by current techniques. The high-performance fully automated AQS3pro system and AQS3delta analytics package allow scientists to quickly and easily run samples, process data and gain insight.

AQS3pro

Next generation in protein structure determination.

The AQS³pro powered by Microfluidic Modulation Spectroscopy is the next generation infrared based spectroscopy platform for protein structure determination. It represents a novel tool that will strengthen you bioanalytical tool kit and provide critical insights into protein based drug development.

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