Application Note

Analysis of NIST Monoclonal Antibody Structure with Microfluidic Modulation Spectroscopy (MMS)

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Application Note

This Application Note Includes:

  • NIST mAb RM 8671 is evaluated by MMS, which proves to be a uniquely valuable method for the measurement of higher order structure (HOS) across a wide concentration range
  • MMS yields high quality, reproducible spectra over the measured concentration range.  
  • MMS achieves higher sensitivity across a wider concentration range compared
    to current FTIR techniques

Characterizing Monoclonal Antibody Structure In 2016 the National Institute of Standards and Technology (NIST) made NISTmAb Reference Material (RM) 8671 commercially available for the evaluation of methods used to characterize the structure of monoclonal antibodies. This then serves as a performance control against which novel processes and emerging characterization technologies could be compared. Because this mAb is so widely characterized, its evaluation using Microfluidic Modulation Spectroscopy (MMS) is an important measurement and the first step in characterizing mAbs against a reputable standard.

Change How You See Biomolecules

Microfluidic Modulation Spectroscopy provides a powerful alternative, producing consistently reproducible data that goes beyond that supplied by current techniques. The high-performance fully automated AQS3pro system and AQS3delta analytics package allow scientists to quickly and easily run samples, process data and gain insight.


Next generation in protein structure determination.

The AQS³pro powered by Microfluidic Modulation Spectroscopy is the next generation infrared based spectroscopy platform for protein structure determination. It represents a novel tool that will strengthen you bioanalytical tool kit and provide critical insights into protein based drug development.
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