Application Note

Comparison of FTIR protein analysis and Microfluidic Modulation Spectroscopy: Assessment of Quantitation Linearity for Bovine Serum Albumin

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Application Note

This Application Note Includes:

  • BSA was prepared as a series and examined by MMS to measure the concentration linearity of the series.
  • Measures protein secondary structure by combining infrared spectroscopy with microfluidics to enhance sensitivity and accuracy
  • Achieves higher sensitivity across a wider concentration range compared to current FTIR techniques

FTIR Protein Analysis Of MMS

Microfluidic Modulation Spectroscopy (MMS) is a revolutionary new technology capable of highly sensitive and reproducible measurements of protein secondary structure using IR absorbance in the Amide I band (1700-1600 cm-1). MMS is performed on the AQS3pro system from RedShift BioAnalytics, and it generates measurements over a wide range of complex backgrounds. The AQS3pro operates using a quantum cascade laser in combination with a microfluidic flow cell resulting in a wide dynamic range of 0.1 to >200 mg/mL for structural characterization, and further extended to 0.01 to >200 mg/mL for quantitation measurements.

Change How You See Biomolecules

Microfluidic Modulation Spectroscopy provides a powerful alternative, producing consistently reproducible data that goes beyond that supplied by current techniques. The high-performance fully automated AQS3pro system and AQS3delta analytics package allow scientists to quickly and easily run samples, process data and gain insight.


Next generation in protein structure determination.

The AQS³pro powered by Microfluidic Modulation Spectroscopy is the next generation infrared based spectroscopy platform for protein structure determination. It represents a novel tool that will strengthen you bioanalytical tool kit and provide critical insights into protein based drug development.
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