Physicochemical Characterization of ADCs (Antibody-Drug Conjugates)

Webinar Length: 1 hour

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In this webinar you will learn:

  • Analysis of the higher order structure (HOS) of therapeutic antibodies and antibody drug conjugates.
  • Study of the effects in secondary structure of conjugated proteins.
  • How the AQS3pro, with Microfluidic Modulation Spectroscopy, provides reliability, increased sensitivity and higher resolution for secondary structure analysis of biotherapeutics.


Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess biophysical properties of antibody-drug conjugates (ADCs). For ADCs, the level of payload and site of conjugation are determined using LC/MS. Thermal stability and binding affinity are characterized using DSC, IR, and ITC. These methods, along with MMS, can be used for the in-depth analysis of these biologics and for routine product validation.